abstract：BACKGROUND:Important progress has been made in our understanding of the autoimmune neuromuscular transmission (NMT) disorders; myasthenia gravis (MG), Lambert-Eaton myasthenic syndrome (LEMS) and neuromyotonia (Isaacs' syndrome). METHODS:To prepare consensus guidelines for the treatment of the autoimmune NMT disorders...

journal_title：European journal of neurology

authors： Skeie GO,Apostolski S,Evoli A,Gilhus NE,Illa I,Harms L,Hilton-Jones D,Melms A,Verschuuren J,Horge HW,European Federation of Neurological Societies.

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND:The purpose of the study is to investigate the epidemiology and medical expenses of Wilson's disease in Taiwan. METHODS:Cases of Wilson's disease were identified from the National Health Insurance Research Database with corresponding International Classification of Diseases, Ninth Revision (ICD-9) code 275....

journal_title：European journal of neurology

authors： Lai CH,Tseng HF

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:Clinical presentation and DYT1 status amongst Chinese patients with primary dystonia have not been well studied. METHODS:One hundred and twenty patients with primary dystonia from South-West China were studied in a prospective survey for 3.5 years. Severity and the resulting disability were assessed using t...

journal_title：European journal of neurology

authors： Zhang SS,Fang DF,Hu XH,Burgunder JM,Chen XP,Zhang YW,Shang HF

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Mutations in fused in sarcoma (FUS) were recently identified as a cause of familial amyotrophic lateral sclerosis (ALS). The frequency of occurrence of mutations in FUS in sets of patients with familial ALS remains to be established. METHODS:We sequenced the FUS gene in a cohort of patients with...

journal_title：European journal of neurology

authors： Damme PV,Goris A,Race V,Hersmus N,Dubois B,Bosch LV,Matthijs G,Robberecht W

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND:Patients with Parkinson's disease (PD) and chronically treated with L-DOPA exhibit, in a percentage of 10-30%, supra-physiological levels of plasma total homocysteinemia (tHcy). In this study, we have investigated, in a group of hyper-homocysteinemic PD patients, the time of hyper-tHcy recurrence after disco...

journal_title：European journal of neurology

authors： Belcastro V,Pierguidi L,Castrioto A,Menichetti C,Gorgone G,Ientile R,Pisani F,Rossi A,Calabresi P,Tambasco N

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND:Cognitive tests are known to be influenced by language, culture and education. In addition, there may be an impact of 'epoch' in cognition, because there is secular increase in scores of IQ tests in children. If we assume this is a long lasting process, then it should persist later in life. METHODS:To test ...

journal_title：European journal of neurology

authors： Morgado J,Rocha CS,Maruta C,Guerreiro M,Martins IP

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND:Several metabolic derangements associated with diabetes mellitus type 2 (DM) have been associated with a better outcome in amyotrophic lateral sclerosis (ALS), including hyperlipidemia and obesity. Here, we tested the hypothesis that DM would have a positive effect on the motor and cognitive findings of ALS....

journal_title：European journal of neurology

authors： Jawaid A,Salamone AR,Strutt AM,Murthy SB,Wheaton M,McDowell EJ,Simpson E,Appel SH,York MK,Schulz PE

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND:Oxidative stress is a central factor in the pathogenesis of Parkinson's disease (PD). Heme oxygenase-1 (HO-1) is an antioxidant protein expressed in response to oxidative challenge, and its expression levels are inversely correlated with glycogen synthase kinase-3beta (GSK3beta) activity. Underexpression of ...

journal_title：European journal of neurology

authors： Infante J,García-Gorostiaga I,Sánchez-Juan P,Sierra M,Martín-Gurpegui JL,Terrazas J,Mateo I,Rodríguez-Rodríguez E,Berciano J,Combarros O

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:In a longitudinal population-based dataset of patients with multiple sclerosis (MS), we have previously observed a substantial increase in the female to male sex ratio in Canada over the last 50 years. Here, we aimed to determine whether this change in sex ratio is related to the clinical course ...

journal_title：European journal of neurology

authors： Ramagopalan SV,Byrnes JK,Orton SM,Dyment DA,Guimond C,Yee IM,Ebers GC,Sadovnick AD

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:McLeod neuroacanthocytosis syndrome (MLS) is an X-linked multisystem disorder with CNS manifestations resembling Huntington disease. Neuroimaging studies revealed striatal atrophy with predominance of the caudate nucleus. Our previous cross-sectional MRI study showed an association of volume loss...

journal_title：European journal of neurology

authors： Valko PO,Hänggi J,Meyer M,Jung HH

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:The objective of this study was to clarify the influence of regional cerebral blood flow (rCBF) changes in language-relevant areas of the dominant hemisphere on rCBF in each region in the non-dominant hemisphere in post-stroke aphasic patients. METHODS:The study subjects were 27 aphasic patients who suffere...

journal_title：European journal of neurology

authors： Uruma G,Kakuda W,Abo M

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:Consensus guidelines on the definition, investigation, and treatment of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) have been previously published in European Journal of Neurology and Journal of the Peripheral Nervous System. OBJECTIVES:To revise these guidelines. METHODS:Disease exper...

journal_title：European journal of neurology

authors： Van den Bergh PY,Hadden RD,Bouche P,Cornblath DR,Hahn A,Illa I,Koski CL,Léger JM,Nobile-Orazio E,Pollard J,Sommer C,van Doorn PA,van Schaik IN,European Federation of Neurological Societies.,Peripheral Nerve Society.

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The guidelines for chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) therapy suggest to use immunoglobulins (IVIg) and steroid as first-line therapies. Patients who do not respond to one of the two drugs should be switched to the other drug. We collected therapeutic outcome data in...

journal_title：European journal of neurology

authors： Cocito D,Paolasso I,Antonini G,Benedetti L,Briani C,Comi C,Fazio R,Jann S,Matà S,Mazzeo A,Sabatelli M,Nobile-Orazio E,Italian Network for CIDP Register.

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND:Histamine N-methyltransferase (HNMT) is the main metabolizing enzyme of histamine (a mediator of inflammation implicated in the pathogenesis of multiple sclerosis-MS) in the CNS. We have investigated the possible association between a single nucleotide polymorphism of the HNMT (chromosome 2q22.1), that cause...

journal_title：European journal of neurology

authors： García-Martín E,Martínez C,Benito-León J,Calleja P,Díaz-Sánchez M,Pisa D,Alonso-Navarro H,Ayuso-Peralta L,Torrecilla D,Agúndez JA,Jiménez-Jiménez FJ

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND:Pre-treatment with antiplatelet agents (AP) is present amongst 30% of acute stroke patients. Previous studies have shown conflicting results on the effect of these drugs regarding haemorrhagic transformation after thrombolytic therapy. The hypothesis that pre-treatment with AP may increase the risk of cerebr...

journal_title：European journal of neurology

authors： Dorado L,Millán M,de la Ossa NP,Guerrero C,Gomis M,López-Cancio E,Ricciardi AC,Dávalos A

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The relative frequency of the different autosomal dominant cerebellar ataxia (ADCA) varies widely amongst different geographic locations. Here we describe a series of 45 ADCA families from Portugal. METHODS:Patients with progressive cerebellar dysfunction of autosomal dominant transmission under...

journal_title：European journal of neurology

authors： Vale J,Bugalho P,Silveira I,Sequeiros J,Guimarães J,Coutinho P

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:Limited information is available about the impact of seizures on stroke outcome, health care delivery and resource utilization. OBJECTIVE:To determine whether the presence of seizures after stroke increases disability, mortality and health care utilization (length of hospital stay, ICU admission, consults...

journal_title：European journal of neurology

authors： Burneo JG,Fang J,Saposnik G,Investigators of the Registry of the Canadian Stroke Network.

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Multiple sclerosis (MS) patients are often emotionally disturbed. We investigated anger in these patients in relation to demographic, clinical, and mood characteristics. PATIENTS AND METHODS:About 195 cognitively unimpaired MS patients (150 relapsing-remitting and 45 progressive) were evaluated ...

journal_title：European journal of neurology

authors： Nocentini U,Tedeschi G,Migliaccio R,Dinacci D,Lavorgna L,Bonavita S,Bresciamorra V,Comanducci G,Coniglio G,Livrea P,Mannu R,Orefice G,Paciello M,Patti F,Quattrone A,Salemi G,Savettieri G,Simone IL,Valentino P,Zappia

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Botulinum toxin type A (BoNT/A) is a highly effective and well-tolerated treatment for focal dystonias. The BoNT/A in Botox and Dysport is part of a high-molecular-weight complex that contains hemagglutinins and other non-toxic proteins, whilst Xeomin is a highly purified BoNT/A free of such comp...

journal_title：European journal of neurology

authors： Benecke R

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Despite numerous studies, the role of patent foramen ovale (PFO) as a risk factor for stroke due to paradoxical embolism is still controversial. On the assumption that specific lesion patterns, in particular multiple acute ischaemic lesions on diffusion-weighted magnetic resonance imaging, indica...

journal_title：European journal of neurology

authors： Feurer R,Sadikovic S,Esposito L,Schwarze J,Bockelbrink A,Hemmer B,Sander D,Poppert H

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND:The frequency of sural sensory nerve action potential (SNAP) abnormalities in large fibre sensory neuropathy (LFSN) is uncertain. When sural SNAPs are normal, the sural/radial amplitude ratio (SRAR) was found to improve diagnostic yield in some studies. Motor parameters have been studied rarely, but may be h...

journal_title：European journal of neurology

authors： Rajabally YA,Beri S,Bankart J

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Anticipatory postural adjustments (APAs), prior to step initiation, are bradykinetic in advanced Parkinson's disease (PD) and may be one of the factors associated with 'start hesitation'. However, little is known about APAs in the early stage of PD. In this study, we determined whether body-worn ...

journal_title：European journal of neurology

authors： Mancini M,Zampieri C,Carlson-Kuhta P,Chiari L,Horak FB

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:These EFNS guidelines on the molecular diagnosis of neurogenetic disorders are designed to provide practical help for the general neurologist to make appropriate use of molecular genetics in diagnosing neurogenetic disorders. Since the publication of the first two EFNS-guideline papers on the mol...

journal_title：European journal of neurology

authors： Harbo HF,Finsterer J,Baets J,Van Broeckhoven C,Di Donato S,Fontaine B,De Jonghe P,Lossos A,Lynch T,Mariotti C,Schöls L,Spinazzola A,Szolnoki Z,Tabrizi SJ,Tallaksen C,Zeviani M,Burgunder JM,Gasser T,EFNS.

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND:Elevated total homocysteine (tHcy) levels may be caused by vitamin B12 deficiency and are linked to Alzheimers disease (AD) in some studies, although the evidence is mixed. Another marker of vitamin B12 deficiency, holo-transcobalamin (holo-TC), has not been studied in a prospective setting. OBJECTIVE:To in...

journal_title：European journal of neurology

authors： Kivipelto M,Annerbo S,Hultdin J,Bäckman L,Viitanen M,Fratiglioni L,Lökk J

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND:Peritumoral brain edema in glioblastoma patients is a frequently encountered phenomenon that strongly contributes to neurological signs and symptoms. The role of peritumoral edema as a prognostic factor is controversial. MATERIALS AND METHODS:This multi-centre clinical retrospective study included 110 patie...

journal_title：European journal of neurology

authors： Schoenegger K,Oberndorfer S,Wuschitz B,Struhal W,Hainfellner J,Prayer D,Heinzl H,Lahrmann H,Marosi C,Grisold W

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Prevalence of essential tremor (ET), one of the most common movement disorders, has not been properly evaluated amongst heterogeneous population in India. METHODS:We conducted a cross-sectional epidemiological study on the prevalence of ET in a randomly stratified population in the metropolitan ...

journal_title：European journal of neurology

authors： Das SK,Banerjee TK,Roy T,Raut DK,Chaudhuri A,Hazra A

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Educating the public to screen for vascular risk factors and have them treated is a major public health issue. We assessed the vascular risk factor awareness and frequency of treatment in a cohort of patients with cerebral ischaemia. METHODS:Data on awareness and pharmacological treatment of vas...

journal_title：European journal of neurology

authors： Nolte CH,Jungehulsing GJ,Rossnagel K,Roll S,Haeusler KG,Reich A,Willich SN,Villringer A,Muller-Nordhorn J

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Amyotrophic lateral sclerosis (ALS) is classically assumed to be a neurodegenerative disorder. Inflammation has been observed in CNS tissue in ALS patients. We investigated the expression and prognostic relevance of proinflammatory chemokines in ALS. METHODS:We analyzed nine chemokines, eotaxin,...

journal_title：European journal of neurology

authors： Kuhle J,Lindberg RL,Regeniter A,Mehling M,Steck AJ,Kappos L,Czaplinski A

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The 'hot cross bun' sign (HCBS), typically seen in the patients with multiple system atrophy, refers to a cruciform hyperintensity in the pons on T2-weighted MRI. Little is known about its pathological basis and prevalence in other degenerative cerebellar diseases and healthy population. We inves...

journal_title：European journal of neurology

authors： Lee YC,Liu CS,Wu HM,Wang PS,Chang MH,Soong BW

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND:Investigations on cause of death may provide valuable information about life expectancy and on conditions of terminal dementia care, which perhaps can be ameliorated. METHODS:The autopsy reports were studied on all patients (n = 524; 55.3% females; median age 80 years) with a clinically and neuropathologica...

journal_title：European journal of neurology

authors： Brunnström HR,Englund EM

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND:Idiopathic inflammatory demyelinating disorders (IIDD) affect the central nervous system. In classical multiple sclerosis (CMS), brain, optic nerves [optic neuritis (ON)] and spinal cord [acute transverse myelitis (ATM)] are affected. In neuromyelitis optica (NMO), optic nerves and spinal cord are predominan...

journal_title：European journal of neurology

authors： Chan KH,Ramsden DB,Yu YL,Kwok KH,Chu AC,Ho PW,Kwan JS,Lee R,Lim E,Kung MH,Ho SL

更新日期：2009-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Although there are a number of positive reports on the therapeutic effects of repetitive transcranial magnetic stimulation (rTMS) for treatment of tinnitus, there are few details about the duration of treatment effects or the relative efficiency of different rTMS protocols. METHODS:Sixty six pat...

journal_title：European journal of neurology

authors： Khedr EM,Rothwell JC,El-Atar A

更新日期：2009-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:To examine the relative risk (RR) for living in nursing homes for patients with Parkinson's disease (PD) compared with the general population and to ascertain society's costs related to nursing home placement for this patient group. METHODS:We evaluated the frequency of admission to nursing home...

journal_title：European journal of neurology

authors： Vossius C,Nilsen OB,Larsen JP

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND:Prevalence rates of headache in multiple sclerosis (MS) patients varied widely in recent studies. This study aimed to investigate the 1 year prevalence of headache in MS compared with the general population. METHODS:Population-based case-control study in Germany. RESULTS:We included 491 patients with defin...

journal_title：European journal of neurology

authors： Putzki N,Pfriem A,Limmroth V,Yaldizli O,Tettenborn B,Diener HC,Katsarava Z

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The diagnosis of cytomegalovirus encephalitis (CMV-E) in AIDS patients is challenging as other illnesses may obscure the symptoms. Here, we characterize the clinical symptoms of CMV-E and link them to post-mortem findings. Patients and methods In 254 homosexual men with AIDS, followed from HIV di...

journal_title：European journal of neurology

authors： Pirskanen-Matell R,Grützmeier S,Nennesmo I,Sandström E,Ehrnst A

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The purpose of this study was to analyse the long-term impact of Guillain-Barré syndrome (GBS) on quality of life, and the relationship between clinical variables at disease onset and symptoms at follow-up to general health status. METHODS:Forty-two GBS patients were examined at median 6 years a...

journal_title：European journal of neurology

authors： Rudolph T,Larsen JP,Farbu E

更新日期：2008-12-01 00:00:00

abstract：INTRODUCTION:An association between parental smoking and multiple sclerosis (MS) in offspring has been reported. This study examined whether maternal smoking during pregnancy is associated with MS in offspring. METHODS:Swedish general population registers provided prospectively recorded information on maternal smoking...

journal_title：European journal of neurology

authors： Montgomery SM,Bahmanyar S,Hillert J,Ekbom A,Olsson T

更新日期：2008-12-01 00:00:00

abstract：:Allodynia--perception of pain from non-noxious stimuli--is a common clinical feature in various pain syndromes. The significance for migraine has increasingly been recognized and the pathophysiology has been investigated in detail. Allodynia is a marker for sensitization of central trigeminal neurons. Intensity and pe...

journal_title：European journal of neurology

authors： Schürks M,Diener HC

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND:X-linked Charcot-Marie-Tooth disease (CMTX), caused by mutations in the gene encoding connexin32, is the second most common form of inherited demyelinating neuropathy, next to CMT 1A, and accounts for 10-20% of all hereditary demyelinating neuropathies. AIMS OF THE STUDY:To describe clinical and electrophys...

journal_title：European journal of neurology

authors： Mazzeo A,Di Leo R,Toscano A,Muglia M,Patitucci A,Messina C,Vita G

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Differentiation between parkinsonian type multiple system atrophy (MSA-P) and Parkinson's disease (PD) is important but often difficult. We investigated the diagnostic value of brain magnetic resonance imaging (MRI) and (18)F-fluorodeoxyglucose positron emission tomography ((18)F-FDG PET) in diff...

journal_title：European journal of neurology

authors： Kwon KY,Choi CG,Kim JS,Lee MC,Chung SJ

更新日期：2008-10-01 00:00:00